Optimizing Cell-Based Therapy for Cardiac Regeneration
نویسندگان
چکیده
منابع مشابه
Optimizing cell-based therapy for cardiac regeneration.
Long thought to be a terminally differentiated organ, recent findings suggest that the adult mammalian heart is a slowly regenerating organ1 and home to a resident population of cardiac progenitor cells (CPCs) that renew cardiomyocytes and have the potential to differentiate into multiple cell types within the myocardium.2 In spite of this, the regenerative capacity of the mammalian heart is in...
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Stem cell therapy and tissue engineering represent a forefront of current research in the treatment of heart disease. With these technologies, advancements are being made into therapies for acute ischemic myocardial injury and chronic, otherwise nonreversible, myocardial failure. The current clinical management of cardiac ischemia deals with reestablishing perfusion to the heart but not dealing...
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Copyright: © 2014 Masumoto H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Cardiovascular disease remains the leading cause of death worldwide. A boundary for conventional severe heart failure treatm...
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966 The Journal of Thoracic and Cardio In this issue, McConnell and colleagues 1 report a detailed examination of the impact of autologous skeletal myoblast transplantation in a chronic ischemic cardiomyopathy model in sheep. They injected the cells prepared by GenVec, Inc, at multiple sites in the infarct zone. They concluded that cardiac contractility was not improved, but cell implantation p...
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Without heart transplantation, a large number of patients with failing hearts worldwide face poor outcomes. By means of cardiomyocyte regeneration, cardiac regeneration therapy is emerging with great promise as a means for restoring loss of cardiac function. However, the limited success of clinical trials using bone marrow-derived cells and myoblasts with heterogeneous constituents, transplante...
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ژورنال
عنوان ژورنال: Circulation
سال: 2009
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.109.887836